Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors
作者： Alena Kopkova , Jiri Sana , Pavel Fadrus , Ondrej Slaby
关键词:
摘要: Cerebrospinal fluid (CSF) is a body that has many important functions and in direct contact with the extracellular environment of central nervous system (CNS). CSF serves as both communication channel allowing distribution various substances among CNS cells storage facility for waste products these release. For reasons, potential source diagnostic biomarkers diseases, including brain tumors. Recent studies have revealed also contains circulating microRNAs (miRNAs), short non-coding RNAs been described cancers. However, miRNAs are difficult to detect, which why researchers face major challenges, technological difficulties its detection lack standardization. Therefore, this review aims (i) highlight diagnostic, prognostic predictive tumors, (ii) summarize approaches miRNAs.
sci-hub.se 参考文章(41)
Jiri Sana, Marian Hajduch, Jaroslav Michalek, Rostislav Vyzula, Ondrej Slaby, MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications. Journal of Cellular and Molecular Medicine. ,vol. 15, pp. 1636- 1644 ,(2011) , 10.1111/J.1582-4934.2011.01317.X
Tarek Shalaby, Michael Grotzer, Tumor-Associated CSF MicroRNAs for the Prediction and Evaluation of CNS Malignancies International Journal of Molecular Sciences. ,vol. 16, pp. 29103- 29119 ,(2015) , 10.3390/IJMS161226150
MichaelA Grotzer, Tarek Shalaby, Giulio Fiaschetti, Sylvain Baulande, NicolasU Gerber, Martin Baumgartner, Detection and quantification of extracellular microRNAs in medulloblastoma Journal of Cancer Metastasis and Treatment. ,vol. 1, pp. 67- 75 ,(2015) , 10.4103/2394-4722.157068
Argonde C. van Harten, Joyce Mulders, Philip Scheltens, Wiesje M. van der Flier, Cees B.M. Oudejans, Differential Expression of microRNA in Cerebrospinal Fluid as a Potential Novel Biomarker for Alzheimer’s Disease Journal of Alzheimer's Disease. ,vol. 47, pp. 243- 252 ,(2015) , 10.3233/JAD-140075
Wen-Dong You, Qi-Lin Tang, Lei Wang, Jin Lei, Jun-Feng Feng, Qing Mao, Guo-Yi Gao, Ji-Yao Jiang, Alteration of microRNA expression in cerebrospinal fluid of unconscious patients after traumatic brain injury and a bioinformatic analysis of related single nucleotide polymorphisms Chinese journal of traumatology. ,vol. 19, pp. 11- 15 ,(2016) , 10.1016/J.CJTEE.2016.01.004
Johnny C. Akers, Valya Ramakrishnan, Isaac Yang, Wei Hua, Ying Mao, Bob S. Carter, Clark C. Chen, Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid. Cancer Biomarkers. ,vol. 17, pp. 125- 132 ,(2016) , 10.3233/CBM-160609
Fredrik Piehl, Maja Jagodic, Petra Bergman, Eliane Piket, Mohsen Khademi, Tojo James, Lou Brundin, Tomas Olsson, Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis. Neuroimmunology and Neuroinflammation. ,vol. 3, ,(2016) , 10.1212/NXI.0000000000000219
Traek Shalaby, Federica Achini, Michael A. Grotzer, Targeting cerebrospinal fluid for discovery of brain cancer biomarkers Journal of Cancer Metastasis and Treatment. ,vol. 2, pp. 176- 187 ,(2016) , 10.20517/2394-4722.2016.12
Manish Bhomia, Nagaraja S. Balakathiresan, Kevin K. Wang, Linda Papa, Radha K. Maheshwari, A Panel of Serum MiRNA Biomarkers for the Diagnosis of Severe to Mild Traumatic Brain Injury in Humans. Scientific Reports. ,vol. 6, pp. 28148- 28148 ,(2016) , 10.1038/SREP28148
Takanori Yokota, Yohsuke Yagi, Takuya Ohkubo, Hideya Kawaji, Akira Machida, Haruka Miyata, Saori Goda, Sugata Roy, Yoshihide Hayashizaki, Harukazu Suzuki, Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes Neuroscience Letters. ,vol. 636, pp. 48- 57 ,(2017) , 10.1016/J.NEULET.2016.10.042