Giant osteoclasts in patients under bisphosphonates.

摘要: Bisphosphonates have been widely used for treatment of high bone resorption states. It lowers turnover by inhibiting osteoclasts with various mechanisms actions: inhibition osteoclast formation and attachment to the surface, induction metabolic injury, alteration vesicle trafficking apoptosis. Bone biopsies studies from patients under bisphosphonates shown that some parameters are decreased as expected but number seems not be necessarily decreased. The description morphology treated has rarely reported in literature. We describe this paper two whom iliac crest large, multinucleated apoptotic were associated activities. characteristics these described literature reviewed. appropriate recognition giant tissues is primary importance pathologists should interpreted signs increased seen hyperparathyroidism, cancer or Paget’s disease bone.