Chemotherapy for advanced non-small-cell lung cancer: how much benefit is enough?
作者： R Grilli , A D Oxman , J A Julian
DOI: 10.1200/JCO.1993.11.10.1866
关键词:
摘要: PURPOSETo estimate the impact of chemotherapy on survival patients with advanced non-small-cell lung cancer (NSCLC).METHODSRandomized controlled trials (RCTs) published in English-language medical literature between 1970 and 1991 were identified through MEDLINE reference lists relevant articles. Six RCTs that accounted for 635 compared first-line supportive care NSCLC reported up to at least 1 year identified. Cumulative proportions 3, 6, 9, 12 months control groups derived from curves.RESULTSWithin each study, effect was estimated a pooled relative risk (RR) across four 3-month periods. An overall RR death (RRM-H) then calculated curve chemotherapy-treated constructed applying (RRW) period. Overall, associated 2...
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