Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets

作者: F. Meyer

DOI: 10.1039/C5CC09414C

关键词:

摘要: Recent advances regarding the synthetic chemistry of fluorinated aziridines, azetidines, pyrrolidines and their lactam/amino acid counterparts are presented. These heterocycles high importance both as building blocks for more complex structures active parts medicinal chemistry-oriented compounds.

参考文章(119)
Andrew T. Brusoe, John F. Hartwig, Palladium-catalyzed arylation of fluoroalkylamines Journal of the American Chemical Society. ,vol. 137, pp. 8460- 8468 ,(2016) , 10.1021/JACS.5B02512
Hae-jun Hwang, Se-Won Kim, Byung Il Lee, Jaekyoo Lee, Ho-Juhn Song, Jong Sung Koh, Jung-Ho Kim, Phil Ho Lee, Jang-Sik Choi, Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 4441- 4446 ,(2015) , 10.1016/J.BMCL.2015.09.011
Rama K. Khangarot, Krishna P. Kaliappan, Stereoselective Synthesis of Trifluoromethyl Analogues of Polyhydroxypyrrolidines European Journal of Organic Chemistry. ,vol. 2013, pp. 2692- 2698 ,(2013) , 10.1002/EJOC.201201599
Philip A. S. Lowden, Aziridine Natural Products – Discovery, Biological Activity and Biosynthesis Wiley‐VCH Verlag GmbH & Co. KGaA. pp. 399- 442 ,(2006) , 10.1002/3527607862.CH11
Yuya Daicho, Naokazu Kano, Mariko Yukimoto, Mao Minoura, Takayuki Kawashima, Synthesis, Structure, and Thermolysis of Tetracoordinated 1λ4,2‐Selenazetidines Bearing Two Chiral Centers at the 3‐ and 4‐Positions Heteroatom Chemistry. ,vol. 25, pp. 492- 499 ,(2014) , 10.1002/HC.21177
Olga I. Shmatova, Nikolay E. Shevchenko, Elisabeth S. Balenkova, Gerd-Volker Röschenthaler, Valentine G. Nenajdenko, Highly β‐Regioselective Friedel–Crafts Aminoalkylation of Pyrroles with Cyclic Perfluoroalkylated Imines European Journal of Organic Chemistry. ,vol. 2013, pp. 3049- 3058 ,(2013) , 10.1002/EJOC.201201725
Vitaliy Petrik, Gerd-Volker Röschenthaler, Dominique Cahard, Diastereoselective synthesis of trans-trifluoromethyl-β-lactams and α-alkyl-β-trifluoromethyl-β-amino esters Tetrahedron. ,vol. 67, pp. 3254- 3259 ,(2011) , 10.1016/J.TET.2011.03.001
Olga I. Shmatova, Valentine G. Nenajdenko, Tetrazole‐Substituted Five, Six, and Seven‐Membered Cyclic Amines Bearing Perfluoroalkyl Groups – Efficient Synthesis by Azido‐Ugi Reaction European Journal of Organic Chemistry. ,vol. 2013, pp. 6397- 6403 ,(2013) , 10.1002/EJOC.201300861
Kiyoshi Tanaka, Sigeaki Nagatani, Masaki Ohsuga, Keiryo Mitsuhashi, Regio- and Stereoselectivity of Cycloadditions of Trifluoromethylated Azomethine Ylide Bulletin of the Chemical Society of Japan. ,vol. 67, pp. 589- 591 ,(1994) , 10.1246/BCSJ.67.589