Stereoselective Synthesis of Trifluoromethyl Analogues of Polyhydroxypyrrolidines
作者： Rama K. Khangarot , Krishna P. Kaliappan
关键词: Chemistry 、 Fluorine 、 Solubility 、 Molecule 、 Nucleophilic addition 、 Bond cleavage 、 Organic chemistry 、 Silane 、 Trifluoromethyl 、 Stereoselectivity
摘要: Incorporation of fluorine atoms into organic molecules significantly enhances many their properties, such as solubility, metabolic stability, and bioavailability. Among organofluorine molecules, trifluoromethylated compounds play a unique important role in agricultural medicinal chemistry. An efficient strategy for the synthesis variety polyhydroxypyrrolidines is described. This involves diastereoselective nucleophilic addition reaciton trimethyl(trifluoromethyl)silane to sugar-derived cyclic nitrones followed by reductive N–O bond cleavage removal benzyl groups.
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