gem-Diamine 1-N-Iminosugars and Related Iminosugars, Candidate of Therapeutic Agents for Tumor Metastasis

摘要: Cancer metastasis is one of the major challenges in cancer research. Inhibitors tumor are rapidly emerging as important new drug candidates for therapy. Tumor formation occurs via a complex multistage process which involves crucial step invasion through basement membrane. cell attachment to membrane laminin, degradation matrix by proteolytic enzymes from and migration New drugs aimed at metabolism surface oligosaccharides and/or catabolism glycoconjugates extracellular could inhibit metastasis. In this article, current progress control gem-diamine 1-N-iminosugars related iminosugars (nojirimycin d-glucaro-delta-lactam), potent specific inhibitors carbohydrate catabolism, has been reviewed. gem-Diamine d-glucuronic acid l-iduronic acid, nojirimycin d-glucaro-delta-lactam suppress B16 melanoma variants 3LL (lung carcinoma) cells reconstituted membrane, pulmonary these mice cKDH-8/11 (liver rats. These results suggest that beta-d-glucuronide alpha-l-iduronide processing carbohydrates may participate That holds promise chemotherapy.