The Default Mode Network and Related Right Hemisphere Structures may be the Key Substrates of Dementia
作者： Donald R. Royall , Raymond F. Palmer , Eric D. Vidoni , Robyn A. Honea , Jeffrey M. Burns
关键词:
摘要: We have employed structural equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., δ) from the that is unrelated a dementing process g'). Together g' and d comprise Spearman's "g". Although represents only minor fraction of total performance, it more strongly associated with dementia severity than g'. In this analysis, we replicate δ new dataspace, University Kansas Brain Aging Project, associate specifically regional grey matter atrophy by voxel-based morphometry magnetic resonance imaging data. The latent variable localizes elements default mode network related structures R hemisphere.
sci-hub.se 参考文章(60)
Peipeng Liang, Zhiqun Wang, Yanhui Yang, Kuncheng Li, Three Subsystems of the Inferior Parietal Cortex Are Differently Affected in Mild Cognitive Impairment Journal of Alzheimer's Disease. ,vol. 30, pp. 475- 487 ,(2012) , 10.3233/JAD-2012-111721
David B. Reuben, Albert L. Siu, An objective measure of physical function of elderly outpatients. The Physical Performance Test. Journal of the American Geriatrics Society. ,vol. 38, pp. 1105- 1112 ,(1990) , 10.1111/J.1532-5415.1990.TB01373.X
Donald R. Royall, Raymond F. Palmer, Sid E. O'Bryant, , Validation of a Latent Variable Representing the Dementing Process Journal of Alzheimer's Disease. ,vol. 30, pp. 639- 649 ,(2012) , 10.3233/JAD-2012-120055
Charles Edward Spearman, The Abilities of Man: Their Nature and Measurement ,(2020)
J. M. Burns, B. B. Cronk, H. S. Anderson, J. E. Donnelly, G. P. Thomas, A. Harsha, W. M. Brooks, R. H. Swerdlow, Cardiorespiratory fitness and brain atrophy in early Alzheimer disease Neurology. ,vol. 71, pp. 210- 216 ,(2008) , 10.1212/01.WNL.0000317094.86209.CB
Charles E. Metz, Basic principles of ROC analysis Seminars in Nuclear Medicine. ,vol. 8, pp. 283- 298 ,(1978) , 10.1016/S0001-2998(78)80014-2
Leonard Berg, Daniel W. McKeel, J. Philip Miller, Martha Storandt, Eugene H. Rubin, John C. Morris, Jack Baty, Mary Coats, Joanne Norton, Alison M. Goate, Joseph L. Price, Marla Gearing, Suzanne S. Mirra, Ann M. Saunders, Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease Relation of Histologic Markers to Dementia Severity, Age, Sex, and Apolipoprotein E Genotype JAMA Neurology. ,vol. 55, pp. 326- 335 ,(1998) , 10.1001/ARCHNEUR.55.3.326
M. Pievani, P.E. Rasser, S. Galluzzi, L. Benussi, R. Ghidoni, F. Sabattoli, M. Bonetti, G. Binetti, P.M. Thompson, G.B. Frisoni, Mapping the effect of APOE ε4 on gray matter loss in Alzheimer's disease in vivo NeuroImage. ,vol. 45, pp. 1090- 1098 ,(2009) , 10.1016/J.NEUROIMAGE.2009.01.009
Susanne G. Mueller, Michael W. Weiner, Leon J. Thal, Ronald C. Petersen, Clifford Jack, William Jagust, John Q. Trojanowski, Arthur W Toga, Laurel Beckett, Alzheimer's Disease Neuroimaging Initiative NeuroImage. ,vol. 45, pp. 183- 189 ,(2008) , 10.1007/978-0-387-72076-0_18
J. C. Morris, The Clinical Dementia Rating (CDR): Current version and scoring rules Neurology. ,vol. 43, pp. 2412- 2414 ,(1993) , 10.1212/WNL.43.11.2412-A