Spatial patterns of atrophy, hypometabolism, and amyloid deposition in Alzheimer's disease correspond to dissociable functional brain networks

摘要: Recent neuroimaging studies of Alzheimer's disease (AD) have emphasized topographical similarities between AD-related brain changes and a prominent cortical association network called the default-mode (DMN). However, specificity distinct imaging abnormalities for DMN compared to other intrinsic connectivity networks (ICNs) limbic heteromodal cortex has not yet been examined systematically. We assessed regional amyloid load using AV45-PET, neuronal metabolism FDG-PET, gray matter volume structural MRI in 473 participants from Disease Neuroimaging Initiative, including preclinical, predementia, clinically manifest AD stages. Complementary region-of-interest voxel-based analyses were used assess stage- modality-specific within seven principle ICNs human as defined by standardized functional atlas. Amyloid deposition dementia showed preference DMN, but high effect sizes also observed neocortical ICNs, most notably frontoparietal-control network. Atrophic specific an anterior network, followed whereas relatively spared. Hypometabolism appeared be mixture both amyloid- atrophy-related profiles. Similar patterns modality-dependent predementia and, deposition, preclinical stage. These quantitative data confirm vulnerability multimodal AD. rather than being selective more generally affect higher order cognitive importantly, profiles these markedly differ aspects pathology.