Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.
作者： Dominika Bratkowska , Adeola Shobo , Sanil Singh , Linda A. Bester , Hendrik G. Kruger
DOI: 10.1016/J.JCHROMB.2015.02.041
关键词:
摘要: Abstract A selective, sensitive and high performance liquid chromatography-tandem mass spectrometry (LC–(ESI)MS/MS) method has been developed validated for the quantification of potent antitubercular drug candidate, PA-824, in rat plasma, lung brain tissues. Sample clean-up involved protein precipitation solid-phase extraction. Chromatographic separation was performed on YMC Triart C18 column (150 mm × 3.0 mm, 3.0 μm). The over concentration range 75–1500 ng/mL 50–1200 ng/g lungs 100–1500 ng/g tissue. Evaluation pharmacokinetic properties PA-824 utilized Sprague Dawley rats with a dosage 20 mg/kg at various time points. new applied successfully determination desorption followed by chromatography ultra-high resolution quadrupole time-of-flight different biological samples.
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