Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis
作者： Yi Lu , Jui-Hsin Su , Chiung-Yao Huang , Yung-Chun Liu , Yao-Haur Kuo
DOI: 10.1248/CPB.58.464
关键词:
摘要: Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of querciformis also afforded cembranoid, querciformolide E (3), four cembranoids 4—7. The structures these compounds elucidated on basis their spectroscopic data. Both 4 5 shown to significantly inhibit accumulation pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
sci-hub.se 参考文章(15)
Yen-Hsuan Jean, Wu-Fu Chen, Chun-Sung Sung, Chang-Yih Duh, Shi-Ying Huang, Chan-Shing Lin, Ming-Hon Tai, Shun-Fen Tzeng, Zhi-Hong Wen, Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. British Journal of Pharmacology. ,vol. 158, pp. 713- 725 ,(2009) , 10.1111/J.1476-5381.2009.00323.X
Y. Kashman, M. Bodner, Y. Loya, Y. Benayahu, Cembranolids from Marine Origin (Red Sea), Survey, and Isolation of a New Sinulariolide Derivative Israel Journal of Chemistry. ,vol. 16, pp. 1- 3 ,(1977) , 10.1002/IJCH.197700002
Yen-Hsuan Jean, Wu-Fu Chen, Chang-Yi Duh, Shi-Ying Huang, Chi-Hsin Hsu, Chan-Shing Lin, Chun-Sung Sung, I-Ming Chen, Zhi-Hong Wen, Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni. European Journal of Pharmacology. ,vol. 578, pp. 323- 331 ,(2008) , 10.1016/J.EJPHAR.2007.08.048
Guey-Horng Wang, Chang-Feng Dai, Yao-Haur Kuo, Jyh-Horng Sheu, Atallah F Ahmed, Ru-Ting Shiue, Five novel norcembranoids from Sinularia leptoclados and S. parva Tetrahedron. ,vol. 59, pp. 7337- 7344 ,(2003) , 10.1016/S0040-4020(03)01138-4
Atallah F. Ahmed, Shu-Hui Tai, Zhi-Hong Wen, Jui-Hsin Su, Yang-Chang Wu, Wan-Ping Hu, Jyh-Horng Sheu, A C-3 Methylated Isocembranoid and 10-Oxocembranoids from a Formosan Soft Coral, Sinularia grandilobata Journal of Natural Products. ,vol. 71, pp. 946- 951 ,(2008) , 10.1021/NP7007335
Jui-Hsin Su, Atallah F. Ahmed, Ping-Jyun Sung, Chih-Hua Chao, Yao-Haur Kuo, Jyh-Horng Sheu, Manaarenolides A−I, Diterpenoids from the Soft Coral Sinularia manaarensis Journal of Natural Products. ,vol. 69, pp. 1134- 1139 ,(2006) , 10.1021/NP050483Q
Jui-Hsin Su, Yu-Fang Lin, Yi Lu, Hsiao-Chien Yeh, Wei-Hsien Wang, Tung-Yung Fan, Jyh-Horng Sheu, Oxygenated Cembranoids from the Cultured and Wild-Type Soft Corals Sinularia flexibilis Chemical & Pharmaceutical Bulletin. ,vol. 57, pp. 1189- 1192 ,(2009) , 10.1248/CPB.57.1189
Atallah F. Ahmed, Jui-Hsin Su, Yao-Haur Kuo, Jyh-Horng Sheu, Scabrolides E-G, three new norditerpenoids from the soft coral Sinularia scabra. Journal of Natural Products. ,vol. 67, pp. 2079- 2082 ,(2004) , 10.1021/NP040112U
Ting Wen, Yi Ding, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin, Sinulaflexiolides A−K, Cembrane-Type Diterpenoids from the Chinese Soft Coral Sinularia flexibilis Journal of Natural Products. ,vol. 71, pp. 1133- 1140 ,(2008) , 10.1021/NP070640G
Yen-Ju Tseng, Atallah F. Ahmed, Chang-Feng Dai, Michael Y. Chiang, Jyh-Horng Sheu, Sinulochmodins A-C, three novel terpenoids from the soft coral Sinularia lochmodes. Organic Letters. ,vol. 7, pp. 3813- 3816 ,(2005) , 10.1021/OL051513J