Cytochrome P450 isoenzyme mRNA expression pattern in human urinary bladder malignancies and normal urothelium.

摘要: This study was designed to analyze the cytochrome P450 isoenzyme mRNA expression pattern of transitional cell carcinomas bladder (N = 19) and normal urothelium 10). In addition, biopsies from 32) taken at time transurethral resection cancer in eight patients surrounding histologically also were characterized concerning their specific pattern. A total 13 19 analyzed tumor specimens (68%) revealed 1B1. Cytochrome 4B1 1A1 detected 79% (15 53% (10 specimens, with no correlation between stage grade neoplasm. Biopsies macroscopically tumor-invaded bladders showed 1B1 75% (24 32), 62.5% (20 50% (16 32). Furthermore, a homology observed this bladder. The polymerase chain reaction analysis that do not harbor neoplasm CYP450 for 6 10; 5 2D6 2 2E1 10. According our data, is tumor-specific. present findings are first compare same tumor-bearing bladder, they indicate that, enzymatic point view, panurothelial field disease even urothelium.