Neural Plasticity Following Surgical Correction of Strabismus in Monkeys

摘要: Purpose Although widely practiced, surgical treatment of strabismus has varying levels success and permanence. In this study we investigated adaptive responses within the brain extraocular muscles (EOM) that occur following surgery therefore determine long-term treatment. Methods Single cell were collected from cells in oculomotor abducens nuclei before after two monkeys (M1, M2) with exotropia (divergent strabismus) underwent a correction involved weakening lateral rectus (LR) strengthening medial (MR) muscle one eye. Eye movement neuronal data for up to 10 months during monocular viewing smooth-pursuit task. These fit first-order equation resulting coefficients used estimate population drive (ND) each EOM both eyes. Results Surgery resulted ∼70% reduction angle animals reverted toward presurgical misalignment by approximately 6 first month surgery, ND treated MR reduced animal LR increased other animal, indicating active neural plasticity effectiveness Adaptive changes untreated eye also identified. Conclusions Active corresponding determines longitudinal strabismus. Outcome could be improved identifying ways enhance "positive" adaptation limit "negative" adaptation.