Hyaluronic acid metabolism is increased in unstable plaques

摘要: Eur J Clin Invest 2010; 40 (9): 818–827 Abstract Background  Hyaluronic acid is expressed in atherosclerotic lesions, but its exact role disease remains unknown. As degradation of hyaluronic by hyaluronidase into low molecular weight (LMW-HA) associated with inflammation and Matrix Metalloproteinase (MMP)-9 activity, we hypothesized that metabolism increased plaques unstable characteristics like large lipid core, high number macrophages, MMP-9 collagen smooth muscle cell content. Materials methods  Protein was isolated from 68 carotid artery specimens. The adjacent plaque segment characterized for the histological parameters: macrophage, collagen, (SMC) content amount intra-plaque thrombus. Hyaluronidase total LMW-HA expression, standard hayaluronic receptor CD44s VEGF-A binding isoform CD44v3, activity instability growth factor Vascular Endothial Growth Factor (VEGF)-A were analysed correlated characteristics. Results  CD44 expression (CD44s, CD44v3) levels atheromatous compared fibrous plaques. Total did not correlate instability. CD44s, expression. CD44v3 angiogenic VEGF-A. In vitro stimulation macrophages activity. Conclusions  We show first time elevated are destabilization potentially angiogenesis.