Receptor Tyrosine Kinase Signaling in Vascular Development

摘要: The formation and maintenance of the vascular circulatory system is utmost importance during embryonic postnatal life. first organ to develop cardiovascular network endothelial cells that carry blood metabolites throughout embryo (1 , 2). Indeed, a functional crucial for rapid growth postimplantation embryos. highly dynamic life able generate new capillary cell networks as required, such in wound healing cyclic neovascularization ovarian follicle (corpus luteum) endometrium. Diseases system, including those heart vessels, are major cause pathological conditions affecting humans. Moreover, many cancer secrete angiogenic factors attract neovascuIarize divert flow into solid tumors (3, 4). Abnormal angiogenesis also observed nonneoplastic conditions, diabetic retinopathy, rheumatoid arthritis, psoriasis (4). Our ability understand biochemical mechanisms govern control thus essential development therapies help combat disorders. Endothelial must respond diverse array p0tential signals initiate downstream intracellular pathways can affect their fate, proliferation, transcription, migration, adherence, permeability. Some these may be elicited by transmembrane RTKs,3 because select group molecules expressed at high levels primarily ofthe lineage, FIk-1/KDR, FIt-i FIt-4, Tie-i Tie-2/Tek (5). Furthermore, family act specifically on cells, VEGFs, have been identified ligands capable stimulating tyrosine kinase activity FIk-1 Fit-i FIt-4 receptors. In this review, we describe recent genetic studies mice directly implicate signaling activated