A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.
作者： Michihiro C. Yoshida , Motomichi Sasaki , Masabumi Shibuya , Hitoshi Matsushime
DOI: 10.20772/CANCERSCI1985.78.7_655
关键词:
摘要: We have isolated a human genomic DNA (designated frt) cross-hybridizing with the v-ros oncogene of UR2 sarcoma virus. Sequencing analysis this fragment revealed that sequence contains 123-base-pair exon-like structure surrounded by consensus sequences splice acceptor and donor sites. The deduced amino acid stretch was highly homologous to portion tyrosine kinase domain src family. frt found be conserved in wide variety vertebrates. By using human-mouse hybridoma panel, located on chromosome 13, while c-ros-1 6.
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