The association of metformin use with prostate cancer aggressiveness among Black Americans and White Americans in a population-based study

摘要: Metformin has been associated with a reduced incidence of prostate cancer and improved outcomes. However, whether race modifies the association between metformin use aggressiveness remains uncertain. The was examined separately in Black Americans (Blacks) White (Whites). study population consisted 305 195 research participants incident self-reported diabetes from North Carolina–Louisiana Prostate Cancer Project. High-aggressive defined using composite measure Gleason sum, prostate-specific antigen, clinical stage. Multivariable logistic regression used to assess high-aggressive at diagnosis, among Whites Blacks, adjustment for age, screening history, site, education, insurance, body mass index. positively Blacks (OR 2.01; 95% CI 1.05, 3.83). By contrast, weak inverse found 0.80, 0.34, 1.85). may be modified by race.