Association between metformin therapy and incidence, recurrence and mortality of prostate cancer: evidence from a meta-analysis.

摘要: Objective Previous studies suggested that metformin is associated with decreased risk of cancer; however, results specifically addressing the potential association prostate cancer were limited and contradictory. This study considers between incidence, mortality recurrence by performing a meta-analysis observational studies. Methods Literatures published before January 2014 searched using databases PubMed Embase. Pooled relative risks (RRs) determined random effects model to evaluate strength therapy cancer. Results Thirteen involving total 334 532 participants included in this meta-analysis. Compared control group, was significantly incidence [RR = 0.88, 95% confidence interval (CI) [0.78, 0.99], p = 0.03, I2 = 74.7%]. However, not all-cause (RR = 1.07, CI [0.86, 1.32], p = 0.55, I2 = 58.2%) or (RR = 0.90, [0.75, 1.09], p = 0.27, I2 = 0.0%). No publication bias detected (pBegg = 0.55, pEgger = 0.46). Conclusions The present may decrease but there no treatment recurrence. It recommended finding should be considered carefully confirmed further studies. Copyright © 2015 John Wiley & Sons, Ltd.