Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer.
作者： Amit D. Raval , Malcolm D. Mattes , Suresh Madhavan , Xiaoyun Pan , Wenhui Wei
DOI: 10.1155/2016/2656814
关键词:
摘要: Objective. To examine the association between metformin use and cancer stage at diagnosis among elderly men with preexisting diabetes mellitus incident prostate cancer. Methods. This study used a population-based observational cohort of (≥66 years) 2008 2009 (). Cancer (localized versus advanced) was based on American Joint Committee classification. Metformin other independent variables were measured during one year before diagnosis. Logistic regressions inverse probability treatment weights to control for observed selection bias. Results. A significantly lower percentage users diagnosed advanced as compared nonusers (4.7% 6.7%, ). After adjusting bias variables, associated 32% reduction in risk (adjusted odds ratio, AOR: 0.68, 95% confidence interval, CI: 0.48, 0.97). Conclusions. is first epidemiological support role reducing Randomized clinical trials are needed confirm causal link stage.
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