Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer
作者： Rhonda L Bitting , Andrew J Armstrong
DOI: 10.1530/ERC-12-0394
关键词:
摘要: The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is a key signaling that has been linked to both tumorigenesis and resistance therapy in prostate cancer other solid tumors. Given the significance PI3K/Akt/mTOR integrating cell survival signals high prevalence activating alterations cancer, inhibitors this have great potential for clinical benefit. Here, we review role discuss use as single agents or combination evolving treatment landscape castration-resistant cancer.
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