The Peripheral Actions of the Central Neuropeptide Somatostatin on Control of Breathing

摘要: Abstract Peripherally infused somatostatin in humans reduces the acute ventilatory response to hypoxia but it is not known if basal minute ventilation, and there are conflicting results as whether or hypercapnic response. One explanatory mechanism for all these possible effects that metabolic rate. We therefore tested hypothesis can reduce whole-body rate (measured by gas exchange at mouth) a manner (a) (b) hypoxia, (c) hypercapnia. Seven healthy volunteers underwent two protocols, one with saline control infusion (0.5 mg/h) consisting of 15-min period resting breathing (end-tidal P O 2 held 100 Torr background isocapnia) followed 5 min isocapnic 50 Torr), after 1 min euoxic recovery, hypercapnia CO 45 Torr), recovery. Somatostatin modestly significantly ( p output, uptake. However, did change ventilation. Acute hypoxic was greatly reduced 82% 26%