Assignment of human pancreatic lipase gene (PNLIP) to chromosome 10q24-q26.
作者： Richard C. Davis , Anh Diep , Willi Hunziker , Ivana Klisak , T. Mohandas
DOI: 10.1016/0888-7543(91)90048-J
关键词:
摘要: Human pancreatic lipase (EC 3.1.1.3) is a 56-kDa protein secreted by the acinar pancreas and essential for hydrolysis absorption of long-chain triglyceride fatty acids in intestine. In vivo, 12-kDa cofactor, colipase, required to anchor surface lipid micelles, counteracting destabilizing influence bile salts. Southern blot analysis, using cDNA probe DNA from mouse-human somatic cell hybrids, indicated that gene (PNLIP) resides on human chromosome 10. situ hybridization metaphase chromosomes confirmed hybrid results further localized 10q24-qter region with strongest peak at q26.1.
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