Properties and function of pancreatic lipase related protein 2.

摘要: The lipase gene family includes pancreatic triglyceride and two proteins, related proteins 1 2, with strong nucleotide amino acid sequence homology to lipase. All three have virtually identical three-dimensional structures. Of the homologues, only protein 2 has activity. Like lipase, cleaves triglycerides, but it broader substrate specificity. Pancreatic also hydrolyzes phospholipids galactolipids, fats that are not substrates for rat-related differs from in sensitivity bile salts response colipase. Although pancreas expresses both lipases, their temporal pattern of expression differs. lipase-related mRNA appears before birth persists into adulthood, whereas PTL first at suckling-weanling transition. Additionally, intestinal enterocytes, paneth cells cultured cytotoxic T-cells express encoding 2. A physiological function was demonstrated mice did this protein. deficient malabsorbed fat suckling period, after weaning. They had a defect T-cell mediated cytotoxicity. Thus, is participates activity plays critical role digestion breast milk fats.