Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles
作者： Sara Sánchez-Paradinas , Martín Pérez-Andrés , María Jesús Almendral-Parra , Emilio Rodríguez-Fernández , Ángel Millán
DOI: 10.1016/J.JINORGBIO.2013.10.021
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摘要: Abstract This article explores the potential cytotoxic activity of bile-acid cisplatin derivatives like bisursodeoxycholate(ethylenediamine)platinum(II), PtU2, when conjugated with gold nanoparticles, being a promising alternative to in treatment cancer due their lower toxicity. For our purpose we analyzed intracellular delivery ability these compounds after conjugation 20-nm nanoparticles (PtU2-AuNPs) MG63 (osteosarcoma) cell line. Same platinum uptake incubation PtU2 and PtU2-AuNPs-derivatives is associated higher case platinum–gold nanoparticle conjugate, overall IC50 reduced more than 10 fold for new conjugates. When this derivative efficient compound alone terms activity.
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