DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
作者： Lloyd M. Smith , Robert J. Kaiser , Steven Fung
DOI:
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摘要: The invention consists of compounds and methods for the synthesis oligonucleotides which contain one or more free aliphatic amino groups attached to sugar moieties nucleoside subunits. synthetic method is versatile general, permitting be selectively placed at any position on composition length attainable by current DNA methods. Fluorescent dyes other detectable may covalently yield corresponding modified oligonucleotide.
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