Current Epigenetic Perspective on Diabetes: Who Regulates the Regulators?

摘要: Intensified interest in the development of pharmacological compounds that manipulate gene control highlights importance understanding key players and molecular events driving function. Epigenetic research too frequently focuses on a single chromatinized modification, often at limited number loci, without context for other determinants transcription. This perception is problematic because it implies an oversimplification vastly complex multidimensional network control. It overlooks interactions chromatin modifying enzymes transcription factors, seldom addresses signaling cues influence executive enzymatic machinery regulate epigenome. Here we discuss connectivity complexity epigenetic regulation modifications factors. Using example Set7 methyltransferase, describe recent observations expand biology.