Global Epigenetic Screening Technologies: a Novel Tool to Address Cancer Health Disparities in High-Risk Population Groups

摘要: Racial, ethnic and class disparities in cancer incidence mortality have been well documented. Disparities the utilization of preventive, curative treatment services among minorities reported. Screening can be effective at detecting treatable stages, but a large proportion people risk not screened or are regularly screened, as recommended by American Cancer Society's national guidelines. Early detection technologies potential both influencing from cancer, enhancing primary prevention through removal lesions that could potentially develop into cancer. is an epigenetic disease characterized breakdown DNA methylation histones modification patterns. Epigenetic approaches may contribute to reduction health impacting early increasing options. events represent important mechanism(s) which gene function selectively activated inactivated, genetic non-genetic manifestations. Emerging evidence indicates various alterations, such global modifications hypomethylation, common most types modified environmental exposures throughout life course. A simple, easily explained easy understand non-invasive test, index, screen for several sites once, remove some existing barriers screening utilization, disparities. also prove useful identifying lifestyle factors prevalence other chronic conditions high populations, Puerto Rican populations United States Rico.