Recent Advances in the Development of PET and SPECT Tracers for Brain Imaging
作者： Lei Zhang , Anabella Villalobos
DOI: 10.1016/B978-0-12-396492-2.00008-4
关键词:
摘要: Abstract Positron emission tomography (PET) and single photon computed (SPECT) are radiotracer-based noninvasive imaging techniques that provide quantitative binding information on specific target areas of interest. PET SPECT have been proven to be particularly valuable for targets in the central nervous system, enabling receptor occupancy measurements dose selection clinical candidates. In this review, we compare advantages limitations these two modalities; highlight recent advances field including new tools design principles facilitate tracer development novel PDE10a, ORL1, FAAH tracers; review data brain imaging.
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