Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [18F]labelled radiopharmaceuticals using a Tracerlab FXFN
作者： Xia Shao , Raphaël Hoareau , Brian G. Hockley , Louis J. M. Tluczek , Bradford D. Henderson
DOI: 10.1002/JLCR.1865
关键词: Chemistry 、 Analytical chemistry 、 Stereochemistry 、 Fully automated 、 Organic chemistry 、 Spectroscopy 、 Biochemistry 、 Drug discovery 、 Radiology Nuclear Medicine and imaging
摘要: The field of radiochemistry is moving toward exclusive use automated synthesis modules for production clinical radiopharmaceutical doses. Such a move not only comes with many advantages but also presents radiochemists the challenge re-configuring radiopharmaceuticals that require non-conventional while maintaining full automation. Herein, we continue our series articles showcasing versatility Tracerlab FX by presenting straightforward, fully methods preparing range carbon-11 labeled using FXC-Pro. Strategies [11C]acetate, [11C]carfentanil, [11C]choline, [11C]3-amino-4-[2-[(di(methyl)amino)methyl]phenyl]sulfanylbenzonitrile ([11C]DASB), (+)-a-[11C]dihydroterabenazine ([11C]DTBZ), [11C]flumazenil ([11C]FMZ), meta-hydroxyephedrine ([11C]HED), [11C]methionine, [11C]PBR28, [11C]Pittsburgh Compound B ([11C]PiB), 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP), and [11C]raclopride are presented. Copyright © 2011 John Wiley & Sons, Ltd.
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sci-hub.se 参考文章(72)
David L. Gildersleeve, Satoshi Minoshima, Jeffrey A. Fessler, Robert J. Ackermann, Robert A. Koeppe, Donald M. Wieland, Kirk A. Frey, Kirk A. Frey, David E. Kuhl, James E. Carey, In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM The Journal of Nuclear Medicine. ,vol. 35, pp. 405- 410 ,(1994)
H.-J. Machulla, A. Blocher, M. Kuntzsch, M. Piert, R. Wei, J.R. Grierson, Simplified Labeling Approach for Synthesizing 3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) Journal of Radioanalytical and Nuclear Chemistry. ,vol. 243, pp. 843- 846 ,(2000) , 10.1023/A:1010684101509
Iwao Ojima, Fluorine in medicinal chemistry and chemical biology Wiley. ,(2009) , 10.1002/9781444312096
Victor W. Pike, Christer Halldin, Håkan V. Wikström, Radioligands for the study of brain 5-HT 1A receptors in vivo Progress in Medicinal Chemistry. ,vol. 38, pp. 189- 247 ,(2001) , 10.1016/S0079-6468(08)70094-8
Michael R. Kilbourn, Xia Shao, Fluorine‐18 Radiopharmaceuticals John Wiley & Sons, Ltd. pp. 361- 388 ,(2009) , 10.1002/9781444312096.CH14
David T. Price, Cary N. Robertson, Steven W. Baldwin, Matthew D. Orr, R. Edward Coleman, Thomas J. Polascik, Shuyan Wang, Timothy R. DeGrado, Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. Cancer Research. ,vol. 61, pp. 110- 117 ,(2001)
Morand Piert, Maria Picchio, Leonard I. Wiebe, Gerald Reischl, Piyush Kumar, Hans Jürgen Machulla, Hans Jürgen Wester, Sybille Ziegler, Markus Schwaiger, Roswitha Beck, Alexander J B McEwan, Hypoxia-Specific Tumor Imaging with 18F-Fluoroazomycin Arabinoside The Journal of Nuclear Medicine. ,vol. 46, pp. 106- 113 ,(2005)
D. A. WEBER, J. W. KEYES, S. LANDMAN, G. A. WILSON, COMPARISON OF Tc99m POLYPHOSPHATE AND F18 FOR BONE IMAGING American Journal of Roentgenology. ,vol. 121, pp. 184- 190 ,(1974) , 10.2214/AJR.121.1.184
Timothy R DeGrado, Steven W Baldwin, Shuyan Wang, Matthew D Orr, Ray P Liao, Henry S Friedman, Robert Reiman, David T Price, R Edward Coleman, Synthesis and Evaluation of 18F-Labeled Choline Analogs as Oncologic PET Tracers The Journal of Nuclear Medicine. ,vol. 42, pp. 1805- 1814 ,(2001)
Peter J. H. Scott, Xia Shao, Fully automated, high yielding production of N‐succinimidyl 4‐[18F]fluorobenzoate ([18F]SFB), and its use in microwave‐enhanced radiochemical coupling reactions Journal of Labelled Compounds and Radiopharmaceuticals. ,vol. 53, pp. 586- 591 ,(2010) , 10.1002/JLCR.1785