Does accelerated reproductive aging underlie premenopausal risk for cardiovascular disease

摘要: The menopausal transition is associated with an increase in risk for cardiovascular disease (CVD),1–12 the leading cause of death women.13 As number post-menopausal US women rises,14 proportionate increases CVD will have enormous public health implications. Despite this, there a paucity research examining relation between variability reproductive aging and pre-menopausal period, time when interventions to slow menopause onset and/or lessen clinical impact its sequelae may be possible. Recent methodological advances measurement aging, including assessment Anti-Mullerian hormone (AMH), biochemical marker ovarian reserve, are now opening up new opportunities address this gap our knowledge. AMH secreted by granulosa cells pre-antral small antral follicles human ovary.15 AMH plays key role inhibiting early stages follicle growth, thereby preserving reserve limiting initial recruitment primordial into pool growing follicles.16–17 Because levels reflective follicles, which themselves proportional indexes reserve.18–19 Support use capacity stems from studies showing correlates remaining ovary20; it relates inversely chronological age adult women18, 21; predicts response treatment protocols using assisted technologies22–23 as well fecundity fertile women24; prospectively timing menopause.25–26 also possesses several advantages, making particularly well-suited epidemiological studies. That is, shows excellent within-person cycle-to-cycle reproducibility27–28; stable across menstrual cycle 29–31; not impacted oral contraceptives.31–32. Moreover, has recently been incorporated revised STRAW staging system albeit supportive diagnostic purposes.33 In current study, we evaluated association indexed levels, among 951 regularly-cycling, women. primary study objective was examine overall marked total cardio-metabolic factors calculated sum (ranging 0–5) five components metabolic syndrome: 1) triglycerides ≥150 mg/dL; 2) high-density lipoprotein [HDL] <50 3) homeostasis model insulin resistance [HOMA-IR] ≥2.6; 4) waist circumference ≥88 cm white, African-American, Latina ≥80 Chinese women; 5) hypertensive (versus normotensive) status. Secondarily, were examined each these individually. We hypothesized that having greater higher would related healthier factor profile.