Age and frailty as risk factors for the development of osteoarthritis.
作者： Melissa S. O’Brien , Jason J. McDougall
DOI: 10.1016/J.MAD.2019.03.003
关键词:
摘要: Osteoarthritis (OA) is a degenerative joint disease that increases in prevalence with advanced age. While multitude of factors contribute to the development OA, ageing has been implicated as major driving force leading an inability repair itself and maintain normal health. In aged individuals, changes cellular composition signalling mechanisms have observed which could lead disease. Senescent cells found both OA joints release senescent-associated mediators can destroy articular tissues. These addition chronic pro-inflammatory environment associated may hinder ability culminating OA. We hypothesise frailty also drive by creating inflammatory interfere tissue The molecular biochemical turn promote resulting exorable deterioration joint. Frailty therefore be considered additional risk factor for
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