Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi

摘要: An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis the germ line. Their sequence suggests a role DNA repair and/or replication, chromatin remodeling, or cell cycle control; there are many novel highly conserved from yeast human. Because known mutator causally involved hereditary and sporadic human cancers, it is likely some new mutators equally relevant cancer etiology.