Age-Related Effects on Prefrontal Cortical Systems: Translating Between Rodents, Nonhuman Primates, and Humans

摘要: Impairments in cognition related to dysfunction of the prefrontal cortex occur as a consequence aging rodents, nonhuman primates, and humans. This chapter describes evidence from several different cognitive tasks that can be administered these species, provide convergent about behavioral neurobiological consequences advanced chronological age on function. Aging results impairments spatial working memory, flexibility stimulus–reward associations, shifting attentional sets strategies. These setting which translational studies function conducted, facilitating search for therapeutic strategies improve functions aged