SDMA is an early marker of change in GFR after living-related kidney donation

摘要: * J.T.K. and H.V. contributed equally to the manuscript are both considered first authors. † S.M.B.-B. V.K. last Abstract Background. Early detection of changes in glomerular filtration rate (GFR) is crucial detecting acute kidney injury. There burgeoning evidence from preclinical clinical studies that symmetrical dimethylarginine (SDMA) correlates well with different parameters renal function. In some studies, SDMA even outperformed cre- atinine as a marker GFR. It however unknown how fast increasing after reduction The aim our study was therefore determine temporal change comparison cystatin C defined Methods. Blood samples 24 healthy living-related donors (19 F/5 M), mean age 55.2 ± 8.3 years, were collected prior donation 1, 6, 12, 24, 72 168 h unilateral nephrectomy. levels measured using liquid chromatography-mass spectrometry-based method. Results. Within 6 nephrectomy, i.e. re- duction GFR by 50%, rose 0.571 0.120 0.659 0.135 μmol/L (P < 0.001). Baseline increased 0.87 0.16 1.07 0.15 mg/L Also, serum creatinine sig- nificantly within removal one 65.4 8.4 88.8 10.2 Discussion. might be valuable early experimental set- ting. Future will have clarify whether sensitiv- ity, specificity resolution make it an attractive candidate for assessment func- tion setting.