L-Arginine, ADMA, SDMA, creatinine, MDRD formula: detour to renal function testing.
作者： Jens Martens-Lobenhoffer , Stefan Vollmer , Jan T Kielstein , Stefanie M Bode-Böger
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摘要: We report the case of a 50-year-old woman in whom laboratory work-up for suspected L-arginine deficiency and concomitant determination elevated symmetrical dimethylarginine (SDMA) led to diagnosis chronic kidney disease. This had been missed due '';normal'' serum creatinine. illustrates that patients physicians, while perusing non-evidence-based treatment strategies, such as supplementation, fail recognize importance evidence-based medicine, renal function testing. It also supports notion routine estimation glomerular filtration rate should be mandatory every patient creatinine test is ordered.
参考文章(11)
Carmine Zoccali, Giovanna Parlongo, Belinda Spoto, Rosa M Parlongo, Edoardo Sgro, The enzymatic machinery for ADMA synthesis and degradation is fully expressed in human adipocytes. Journal of Nephrology. ,vol. 20, pp. 554- ,(2007)
Andrew S Levey, Lesley A Stevens, Thomas Hostetter, None, Automatic Reporting of Estimated Glomerular Filtration Rate—Just What the Doctor Ordered Clinical Chemistry. ,vol. 52, pp. 2188- 2193 ,(2006) , 10.1373/CLINCHEM.2006.078733
Andrew M. Wilson, Randall Harada, Nandini Nair, Naras Balasubramanian, John P. Cooke, L-arginine supplementation in peripheral arterial disease - No benefit and possible harm Circulation. ,vol. 116, pp. 188- 195 ,(2007) , 10.1161/CIRCULATIONAHA.106.683656
Andreas Meinitzer, Ursula Seelhorst, Britta Wellnitz, Gabriele Halwachs-Baumann, Bernhard O Boehm, Bernhard R Winkelmann, Winfried März, Asymmetrical Dimethylarginine Independently Predicts Total and Cardiovascular Mortality in Individuals with Angiographic Coronary Artery Disease (The Ludwigshafen Risk and Cardiovascular Health Study) Clinical Chemistry. ,vol. 53, pp. 273- 283 ,(2007) , 10.1373/CLINCHEM.2006.076711
Rainer H Böger, L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous? Current Opinion in Clinical Nutrition and Metabolic Care. ,vol. 11, pp. 55- 61 ,(2008) , 10.1097/MCO.0B013E3282F2B0C3
Josef Coresh, Elizabeth Selvin, Lesley A Stevens, Jane Manzi, John W Kusek, Paul Eggers, Frederick Van Lente, Andrew S Levey, None, Prevalence of Chronic Kidney Disease in the United States JAMA. ,vol. 298, pp. 2038- 2047 ,(2007) , 10.1001/JAMA.298.17.2038
Andrew S Levey, Juan P Bosch, Julia Breyer Lewis, Tom Greene, Nancy Rogers, David Roth, Modification of Diet in Renal Disease Study Group*, A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation Annals of Internal Medicine. ,vol. 130, pp. 461- 470 ,(1999) , 10.7326/0003-4819-130-6-199903160-00002
Jan T. Kielstein, Shelley R. Salpeter, Stefanie M. Bode-Boeger, John P. Cooke, Danilo Fliser, Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis Nephrology Dialysis Transplantation. ,vol. 21, pp. 2446- 2451 ,(2006) , 10.1093/NDT/GFL292
Mark J. Sarnak, Andrew S. Levey, Anton C. Schoolwerth, Josef Coresh, Bruce Culleton, L. Lee Hamm, Peter A. McCullough, Bertram L. Kasiske, Ellie Kelepouris, Michael J. Klag, Patrick Parfrey, Marc Pfeffer, Leopoldo Raij, David J. Spinosa, Peter W. Wilson, Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. ,vol. 108, pp. 2154- 2169 ,(2003) , 10.1161/01.CIR.0000095676.90936.80
Frank C. Brosius, Thomas H. Hostetter, Ellie Kelepouris, Mark M. Mitsnefes, Sharon M. Moe, Michael A. Moore, Subramaniam Pennathur, Grace L. Smith, Peter W.F. Wilson, Detection of Chronic Kidney Disease in Patients With or at Increased Risk of Cardiovascular Disease A Science Advisory From the American Heart Association Kidney and Cardiovascular Disease Council; the Councils on High Blood Pressure Research, Cardiovascular Disease in the Young, and Epidemiology and Prevention; and the Quality of Care and Outcomes Research Interdisciplinary Working Group Developed in Collaboration With the National Kidney Foundation Circulation. ,vol. 114, pp. 1083- 1087 ,(2006) , 10.1161/CIRCULATIONAHA.106.177321