Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis

摘要: Background. Dosing of most drugs must be adapted in renal insufficiency, making accurate assessment function essential clinical medicine. Furthermore, even modest impairment has been recognized as a cardiovascular risk factor. The purpose this analysis was to identify the role symmetric dimethylarginine (SDMA), structural isomer marker asymmetric dimethylarginine, an endogenous function. Methods. Comprehensive searches Medline and Cochrane Library from 1970 February 2006 were performed studies that evaluated correlation between SDMA search augmented by scanning references identified articles reviews. coefficients (R) recorded each study for values 1/SDMA clearance estimates creatinine levels. summary with 95% confidence intervals (CIs) pooled using random-effects method. Results. In 18 involving 2136 patients systemic concentrations correlated highly inulin [R ¼ 0.85 (CI 0.76–0.91, P < 0.0001)], well various combined 0.77 0.65–0.85, 0.0001)] serum 0.75 0.46–089, 0.0001)]. Conclusions. exhibits some properties reliable Future have clarify whether is indeed suited improve diagnosis eventually optimize care patients.