Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes.

摘要: Reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. Voltammetry allows high-speed detection dopamine release projection area. Although voltammetry revealed presynaptic modulation striatum, to date, reward-induced awakened brains recorded only rodents. To make such recordings, it is possible use conventional carbon fibres monkey but these limited by their physical fragility. In this study, constant-potential amperometry was applied novel diamond microelectrodes for dopamine. during Pavlovian cue-reward trials, a sharp response reward cue detected caudate Japanese monkeys. Overall, method measurements monoamine specific target areas large brains, findings from which will expand knowledge responses obtained unit recordings.