Comparative genomic analysis of Brucella abortus vaccine strain 104M reveals a set of candidate genes associated with its virulence attenuation.
作者： Dong Yu , Yiming Hui , Xiaodong Zai , Junjie Xu , Long Liang
DOI: 10.1080/21505594.2015.1038015
关键词:
摘要: The Brucella abortus strain 104M, a spontaneously attenuated strain, has been used as vaccine in humans against brucellosis for 6 decades China. Despite many studies, the molecular mechanisms that cause attenuation are still unclear. Here, we determined whole-genome sequence of 104M and conducted comprehensive comparative analysis whole genome sequences virulent A13334, other reference strains. This revealed highly similar structure between A13334. further genomic A13334 set genes missing 104M. Some these were identified to be directly or indirectly associated with virulence. Similarly, mutations virulence-related was also identified, which may related virulence alteration. study provides candidate B.abortus
sci-hub.se 参考文章(43)
G. A. Kennedy, G. R. Hansen, S. C. Olsen, D. R. Ewalt, D. C. Van Metre, Brucellosis induced by RB51 vaccine in a pregnant heifer. Javma-journal of The American Veterinary Medical Association. ,vol. 215, pp. 1491- 1493 ,(1999)
Gerald L. Mandell, R. Gordon Douglas, John E. Bennett, Principles and Practice of Infectious Diseases ,(1985)
H Cruz-Ramos, P Glaser, L V Wray, S H Fisher, The Bacillus subtilis ureABC operon. Journal of Bacteriology. ,vol. 179, pp. 3371- 3373 ,(1997) , 10.1128/JB.179.10.3371-3373.1997
Oswald R. Crasta, Otto Folkerts, Zhangjun Fei, Shrinivasrao P. Mane, Clive Evans, Susan Martino-Catt, Betsy Bricker, GongXin Yu, Lei Du, Bruno W. Sobral, Genome Sequence of Brucella abortus Vaccine Strain S19 Compared to Virulent Strains Yields Candidate Virulence Genes PLoS ONE. ,vol. 3, pp. e2193- ,(2008) , 10.1371/JOURNAL.PONE.0002193
Mohamed N. Seleem, Stephen M. Boyle, Nammalwar Sriranganathan, Brucella: A pathogen without classic virulence genes Veterinary Microbiology. ,vol. 129, pp. 1- 14 ,(2008) , 10.1016/J.VETMIC.2007.11.023
Gerhardt G. Schurig, R.Martin Roop, T. Bagchi, S. Boyle, D. Buhrman, N. Sriranganathan, Biological properties of RB51; a stable rough strain of Brucella abortus. Veterinary Microbiology. ,vol. 28, pp. 171- 188 ,(1991) , 10.1016/0378-1135(91)90091-S
Bo-Le Jiang, Jiao Liu, Li-Feng Chen, Ying-Ying Ge, Xiao-Hong Hang, Yong-Qiang He, Dong-Jie Tang, Guang-Tao Lu, Ji-Liang Tang, DsbB Is Required for the Pathogenesis Process of Xanthomonas campestris pv. campestris Molecular Plant-microbe Interactions. ,vol. 21, pp. 1036- 1045 ,(2008) , 10.1094/MPMI-21-8-1036
Jean-Pierre Bohin, Osmoregulated periplasmic glucans in Proteobacteria Fems Microbiology Letters. ,vol. 186, pp. 11- 19 ,(2000) , 10.1111/J.1574-6968.2000.TB09075.X
J.M. Blasco, A review of the use of B. melitensis Rev 1 vaccine in adult sheep and goats Preventive Veterinary Medicine. ,vol. 31, pp. 275- 283 ,(1997) , 10.1016/S0167-5877(96)01110-5
H. Kim, W. Jeong, H.-Y. Jeoung, J.-Y. Song, J.-S. Kim, J.-H. Beak, V. Parisutham, S. K. Lee, J. W. Kim, J.-Y. Kim, S. C. Jung, M. Her, D.-J. An, Complete genome sequence of Brucella abortus A13334, a new strain isolated from the fetal gastric fluid of dairy cattle. Journal of Bacteriology. ,vol. 194, pp. 5444- 5444 ,(2012) , 10.1128/JB.01124-12