Brucella: A pathogen without classic virulence genes

摘要: The first species of Brucella was isolated and characterized almost 120 years ago recently the complete nucleotide sequences genomes a number well-characterized strains have been determined. However, compared to other bacterial pathogens relatively little is known about factors contributing its persistence in host multiplication within phagocytic cells. Also, many aspects interaction between their remain unclear. Molecular characterization intracellular survival process important as it will provide guidance for prevention control. One features that distinguish they do not express classical virulence factors. Thus identification has elusive some identifications are putative. Disruption putative genes studying effect on attenuation cell lines or mouse models widely used method. most cases apparent whether mutated encode merely affect metabolic pathways pathogen. In addition, mutations can be compensated by redundancy backup mechanisms. This review examine (real putative) identified date mechanisms contribute ability establish chronic infection.