Bradykinin B1 and B2 receptors, tumour necrosis factor α and inflammatory hyperalgesia
作者： S Poole , B B Lorenzetti , J M Cunha , F Q Cunha , S H Ferreira
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摘要: The effects of BK agonists and antagonists, other hyperalgesic/antihyperalgesic drugs were measured (3 h after injection hyperalgesic drugs) in a model mechanical hyperalgesia (the end-point which was indicated by brief apnoea, the retraction head forepaws, muscular tremor). DALBK inhibited responses to carrageenin, bradykinin, DABK, kallidin. Responses kallidin DABK indomethacin or atenolol abolished combination + atenolol. HOE 140, given 30 min before, but not 2 after, BK, reduced these agents. A small dose DABK+ evoked response similar much larger alone. antagonized 140 whereas only doses BK. with LPS (1 microg) 140. (5 These data suggest: (a) predominant role for B2 receptors mediating that stimulate release, (b) activation cytokine cascade independently both B1 if stimulus is sufficient magnitude.
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