Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery
作者： J. Meng , H. Kong , H. Y. Xu , L. Song , C. Y. Wang
DOI: 10.1002/JBM.A.30315
关键词:
摘要: Blood compatibility has been an occlusion for biomaterials used in the cardiovascular system. In this work, a multiwalled carbon nanotubes-polyurethane composite (MWNT-PU) was prepared through controlled co-precipitation. The surface chemical composition of treated nanotubes analyzed with XPS and thermal behaviors were characterized by DSC. platelet adhesion activation caused evaluated using SEM flow cytometric analysis, respectively, disruption red blood cells measuring absorbance free hemoglobin. experimental results demonstrated that: (1) Multiwalled (MWNTs) oxygen-containing functional groups could be well dispersed polyurethane matrix coprecipitation; (2) displayed significantly improved anticoagulant function, which can indicative promising potentials nanotube-based materials implants medical devices applied blood-contacting environments.
irgrid.ac.cn参考文章(14)
SJ Shattil, M Cunningham, JA Hoxie, Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry Blood. ,vol. 70, pp. 307- 315 ,(1987) , 10.1182/BLOOD.V70.1.307.307
Richard J. Zdrahala, Small Caliber Vascular Grafts. Part I: State of the Art Journal of Biomaterials Applications. ,vol. 10, pp. 309- 329 ,(1996) , 10.1177/088532829601000402
Tz-Chong Chou, Earl Fu, Chang-Jer Wu, Jeng-Hsien Yeh, Chitosan enhances platelet adhesion and aggregation. Biochemical and Biophysical Research Communications. ,vol. 302, pp. 480- 483 ,(2003) , 10.1016/S0006-291X(03)00173-6
J. M. Grunkemeier, W. B. Tsai, T. A. Horbett, Co-adsorbed fibrinogen and von Willebrand factor augment platelet procoagulant activity and spreading Journal of Biomaterials Science-polymer Edition. ,vol. 12, pp. 1- 20 ,(2001) , 10.1163/156856201744416
Brian A. Weisenberg, Daniel L. Mooradian, Hemocompatibility of materials used in microelectromechanical systems: Platelet adhesion and morphologyin vitro Journal of Biomedical Materials Research. ,vol. 60, pp. 283- 291 ,(2002) , 10.1002/JBM.10076
Kazuaki Muramatsu, Masaki Uchida, Hyun-Min Kim, Akira Fujisawa, Tadashi Kokubo, Thromboresistance of alkali- and heat-treated titanium metal formed with apatite. Journal of Biomedical Materials Research Part A. ,vol. 65, pp. 409- 416 ,(2003) , 10.1002/JBM.A.10494
V. Balasubramanian, N. K. Grusin, R. W. Bucher, V. T. Turitto, S. M. Slack, Residence-time dependent changes in fibrinogen adsorbed to polymeric biomaterials. Journal of Biomedical Materials Research. ,vol. 44, pp. 253- 260 ,(1999) , 10.1002/(SICI)1097-4636(19990305)44:3<253::AID-JBM3>3.0.CO;2-K
Hui Hu, Yingchun Ni, Vedrana Montana, Robert C. Haddon, Vladimir Parpura, Chemically Functionalized Carbon Nanotubes as Substrates for Neuronal Growth. Nano Letters. ,vol. 4, pp. 507- 511 ,(2004) , 10.1021/NL035193D
Anya Kuznetsova, Irene Popova, John T. Yates, Michael J. Bronikowski, Chad B. Huffman, Jie Liu, Richard E. Smalley, Henry H. Hwu, Jingguang G. Chen, Oxygen-containing functional groups on single-wall carbon nanotubes: NEXAFS and vibrational spectroscopic studies. Journal of the American Chemical Society. ,vol. 123, pp. 10699- 10704 ,(2001) , 10.1021/JA011021B
Gérard Janvier, Charles Baquey, Christian Roth, Nathalie Benillan, Sylvain Belisle, Jean-François Hardy, Extracorporeal Circulation, Hemocompatibility, and Biomaterials The Annals of Thoracic Surgery. ,vol. 62, pp. 1926- 1934 ,(1996) , 10.1016/S0003-4975(96)00942-3