Nanoscale amphiphilic macromolecules as lipoprotein inhibitors: the role of charge and architecture.

摘要: A series of novel amphiphilic macromolecules composed alkyl chains as the hydrophobic block and poly(ethylene glycol) hydrophilic were designed to inhibit highly oxidized low density lipoprotein (hoxLDL) uptake by synthesizing with negatively charged moieties (ie, carboxylic acids) located in two different blocks. The have molecular weights around 5,500 g/mol, form micelles aqueous solution an average size 20-35 nm, display critical micelle concentration values 10(-7) M. Their charge densities hydrodynamic physiological buffer solutions correlated hydrophobic/ location quantity carboxylate groups. Generally, groups destabilize formation more than block. Although all inhibited unregulated hoxLDL macrophages, inhibition efficiency was influenced charged-carboxylate on macromolecules. Notably, negative is not sole factor reducing uptake. combination smaller size, micellar stability for inhibiting macrophages.