Functions of Intracellular Retinoid Binding-Proteins.

摘要: Multiple binding and transport proteins facilitate many aspects of retinoid biology through effects on transport, cellular uptake, metabolism, nuclear delivery. These include the serum retinol protein sRBP (aka Rbp4), plasma membrane receptor Stra6, intracellular binding-proteins such as retinol-binding (CRBP) retinoic acid (CRABP). transports highly lipophilic an aqueous medium. The major protein, CRBP1, likely enhances efficient use by providing a sink to uptake from or via delivering retinal select enzymes that generate retinyl esters acid, protecting retinol/retinal excess catabolism opportunistic metabolism. Intracellular (CRABP1 2, FABP5) seem have more diverse functions distinctive each, directing catabolism, specific receptors, generating non-canonical actions. Gene ablation does not cause embryonic lethality gross morphological defects. Metabolic functional defects manifested in knockouts CRBP2 CRBP3, however, illustrate their essentiality health, case CRBP2, survival during limited dietary vitamin A. Future studies should continue address molecular interactions occur between targets precise physiologic contributions homeostasis function.