Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.
作者： Dongfeng He , Lihong Ma , Rennan Feng , Liangcai Zhang , Yongshuai Jiang
DOI: 10.1016/J.BIOPHA.2015.08.023
关键词:
摘要: Colorectal cancer (CRC) is the third most common form of and second leading cause cancer-related death in Western countries. In order to detect CRC genetic variants, genome-wide association studies (GWAS) have been performed reported some novel susceptibility variants. RHPN2 located on 9q13.11, which encodes a member rhophilin family Ras-homologous (Rho)-GTPase binding proteins. gene rs10411210 polymorphism was identified be significantly associated with European ancestry. GWAS candidate investigate whether risk European, Asian American populations. However, no association. Evidence shows that variant may prognostic biomarker for patients surgically resected CRC. Here we reevaluated this using large-scale samples from 15 (131580 including 53564 cases 78016 controls) meta-analysis method by searching PubMed Google Scholar databases. We did not identify significant heterogeneity among these (P=0.4201 I(2)=2.8%). Our results showed between (P=9.17E-14, odds ratio (OR)=1.10, 95% confidence interval (CI) 1.07-1.13). subgroup analysis, found population P=5.70E-09, OR=1.14, CI 1.10-1.20 P=3.36E-07, OR=1.11, 1.07-1.16, but P=0.0576, OR=1.05, 1.00-1.09. Collectively, our analysis further highlights colorectal cancer.
sci-hub.se 参考文章(27)
Jonathan A.C Sterne, Matthias Egger, Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. Journal of Clinical Epidemiology. ,vol. 54, pp. 1046- 1055 ,(2001) , 10.1016/S0895-4356(01)00377-8
Ian PM Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Kimberley Howarth, Alan M Pittman, Sarah Spain, Steven Lubbe, Axel Walther, Kate Sullivan, Emma Jaeger, Sarah Fielding, Andrew Rowan, Jayaram Vijayakrishnan, Enric Domingo, Ian Chandler, Zoe Kemp, Mobshra Qureshi, Susan M Farrington, Albert Tenesa, James GD Prendergast, Rebecca A Barnetson, Steven Penegar, Ella Barclay, Wendy Wood, Lynn Martin, Maggie Gorman, Huw Thomas, Julian Peto, D Timothy Bishop, Richard Gray, Eamonn R Maher, Anneke Lucassen, David Kerr, D Gareth R Evans, CORGI Consortium, Clemens Schafmayer, Stephan Buch, Henry Völzke, Jochen Hampe, Stefan Schreiber, Ulrich John, Thibaud Koessler, Paul Pharoah, Tom van Wezel, Hans Morreau, Juul T Wijnen, John L Hopper, Melissa C Southey, Graham G Giles, Gianluca Severi, Sergi Castellví-Bel, Clara Ruiz-Ponte, Angel Carracedo, Antoni Castells, EPICOLON Consortium, Asta Försti, Kari Hemminki, Pavel Vodicka, Alessio Naccarati, Lara Lipton, Judy WC Ho, KK Cheng, Pak C Sham, J Luk, Jose AG Agúndez, Jose M Ladero, Miguel de la Hoya, Trinidad Caldés, Iina Niittymäki, Sari Tuupanen, Auli Karhu, Lauri Aaltonen, Jean-Baptiste Cazier, Harry Campbell, Malcolm G Dunlop, Richard S Houlston, None, A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 Nature Genetics. ,vol. 40, pp. 623- 630 ,(2008) , 10.1038/NG.111
Guiyou Liu, Shuyan Zhang, Zhiyou Cai, Guoda Ma, Liangcai Zhang, Yongshuai Jiang, Rennan Feng, Mingzhi Liao, Zugen Chen, Bin Zhao, Keshen Li, PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population NeuroMolecular Medicine. ,vol. 15, pp. 384- 388 ,(2013) , 10.1007/S12017-013-8225-2
Annika Lindblom, Xiao-Lei Zhou, Tao Liu, Annelie Liljegren, Johanna Skoglund, Tatjana Djureinovic, Colorectal cancer as a complex disease: defining at-risk subjects in the general population – a preventive strategy Expert Review of Anticancer Therapy. ,vol. 4, pp. 377- 385 ,(2004) , 10.1586/14737140.4.3.377
María Dolores Giráldez, Adriana López-Dóriga, Luis Bujanda, Anna Abulí, Xavier Bessa, Ceres Fernández-Rozadilla, Jenifer Muñoz, Miriam Cuatrecasas, Rodrigo Jover, Rosa M. Xicola, Xavier Llor, Josep M. Piqué, Angel Carracedo, Clara Ruiz-Ponte, Angel Cosme, José María Enríquez-Navascués, Victor Moreno, Montserrat Andreu, Antoni Castells, Francesc Balaguer, Sergi Castellví-Bel, , Susceptibility genetic variants associated with early-onset colorectal cancer Carcinogenesis. ,vol. 33, pp. 613- 619 ,(2012) , 10.1093/CARCIN/BGS009
Richard S Houlston, Emily Webb, Peter Broderick, Alan M Pittman, Maria Chiara Di Bernardo, Steven Lubbe, Ian Chandler, Jayaram Vijayakrishnan, Kate Sullivan, Steven Penegar, Luis Carvajal-Carmona, Kimberley Howarth, Emma Jaeger, Sarah L Spain, Axel Walther, Ella Barclay, Lynn Martin, Maggie Gorman, Enric Domingo, Ana S Teixeira, David Kerr, Jean-Baptiste Cazier, Iina Niittymäki, Sari Tuupanen, Auli Karhu, Lauri A Aaltonen, Ian PM Tomlinson, Susan M Farrington, Albert Tenesa, James GD Prendergast, Rebecca A Barnetson, Roseanne Cetnarskyj, Mary E Porteous, Paul DP Pharoah, Thibaud Koessler, Jochen Hampe, Stephan Buch, Clemens Schafmayer, Jurgen Tepel, Stefan Schreiber, Henry Völzke, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Brent W Zanke, Alexandre Montpetit, Thomas J Hudson, Steven Gallinger, Harry Campbell, Malcolm G Dunlop, Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer Nature Genetics. ,vol. 40, pp. 1426- 1435 ,(2008) , 10.1038/NG.262
Ben Zhang, Wei-Hua Jia, Koichi Matsuda, Sun-Seog Kweon, Keitaro Matsuo, Yong-Bing Xiang, Aesun Shin, Sun Ha Jee, Dong-Hyun Kim, Qiuyin Cai, Jirong Long, Jiajun Shi, Wanqing Wen, Gong Yang, Yanfeng Zhang, Chun Li, Bingshan Li, Yan Guo, Zefang Ren, Bu-Tian Ji, Zhi-Zhong Pan, Atsushi Takahashi, Min-Ho Shin, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Soriul Kim, Yoon-Ok Ahn, Andrew T Chan, Jenny Chang-Claude, Martha L Slattery, Stephen B Gruber, Fredrick R Schumacher, Stephanie L Stenzel, Colon Cancer Family Registry (CCFR) Casey Graham, Graham Casey, Hyeong-Rok Kim, Jin-Young Jeong, Ji Won Park, Hong-Lan Li, Satoyo Hosono, Sang-Hee Cho, Michiaki Kubo, Xiao-Ou Shu, Yi-Xin Zeng, Wei Zheng, None, Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk Nature Genetics. ,vol. 46, pp. 533- 542 ,(2014) , 10.1038/NG.2985
Ulrike Peters, Carolyn M Hutter, Li Hsu, Fredrick R Schumacher, David V Conti, Christopher S Carlson, Christopher K Edlund, Robert W Haile, Steven Gallinger, Brent W Zanke, Mathieu Lemire, Jagadish Rangrej, Raakhee Vijayaraghavan, Andrew T Chan, Aditi Hazra, David J Hunter, Jing Ma, Charles S Fuchs, Edward L Giovannucci, Peter Kraft, Yan Liu, Lin Chen, Shuo Jiao, Karen W Makar, Darin Taverna, Stephen B Gruber, Gad Rennert, Victor Moreno, Cornelia M Ulrich, Michael O Woods, Roger C Green, Patrick S Parfrey, Ross L Prentice, Charles Kooperberg, Rebecca D Jackson, Andrea Z Lacroix, Bette J Caan, Richard B Hayes, Sonja I Berndt, Stephen J Chanock, Robert E Schoen, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Bernd Frank, Stéphane Bézieau, Sébastien Küry, Martha L Slattery, John L Hopper, Mark A Jenkins, Loic Le Marchand, Noralane M Lindor, Polly A Newcomb, Daniela Seminara, Thomas J Hudson, David J Duggan, John D Potter, Graham Casey, None, Meta-analysis of new genome-wide association studies of colorectal cancer risk Human Genetics. ,vol. 131, pp. 217- 234 ,(2012) , 10.1007/S00439-011-1055-0
Ulrike Peters, Shuo Jiao, Fredrick R. Schumacher, Carolyn M. Hutter, Aaron K. Aragaki, John A. Baron, Sonja I. Berndt, Stéphane Bézieau, Hermann Brenner, Katja Butterbach, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang–Claude, Stephen J. Chanock, Lin S. Chen, Gerhard A. Coetzee, Simon G. Coetzee, David V. Conti, Keith R. Curtis, David Duggan, Todd Edwards, Charles S. Fuchs, Steven Gallinger, Edward L. Giovannucci, Stephanie M. Gogarten, Stephen B. Gruber, Robert W. Haile, Tabitha A. Harrison, Richard B. Hayes, Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Thomas J. Hudson, David J. Hunter, Rebecca D. Jackson, Sun Ha Jee, Mark A. Jenkins, Wei–Hua Jia, Laurence N. Kolonel, Charles Kooperberg, Sébastien Küry, Andrea Z. LaCroix, Cathy C. Laurie, Cecelia A. Laurie, Loic Le Marchand, Mathieu Lemire, David Levine, Noralane M. Lindor, Yan Liu, Jing Ma, Karen W. Makar, Keitaro Matsuo, Polly A. Newcomb, John D. Potter, Ross L. Prentice, Conghui Qu, Thomas Rohan, Stephanie A. Rosse, Robert E. Schoen, Daniela Seminara, Martha Shrubsole, Xiao–Ou Shu, Martha L. Slattery, Darin Taverna, Stephen N. Thibodeau, Cornelia M. Ulrich, Emily White, Yongbing Xiang, Brent W. Zanke, Yi–Xin Zeng, Ben Zhang, Wei Zheng, Li Hsu, Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis Gastroenterology. ,vol. 144, pp. 799- 807 ,(2013) , 10.1053/J.GASTRO.2012.12.020
Fen-xia Li, Xue-xi Yang, Ni-ya Hu, Hong-yan Du, Qiang Ma, Ming Li, Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population. Chinese Journal of Cancer Research. ,vol. 24, pp. 29- 35 ,(2012) , 10.1007/S11670-012-0029-7