Cimetidine effects on the immunosuppression induced by burn injury
作者： Parviz Kokhaei , Mahdieh Shokrollahi Barough , Zuhair M. Hassan
DOI: 10.1016/J.INTIMP.2014.07.003
关键词:
摘要: Although many studies on the immune response following burn injuries have been reported, more attention has given to immunosuppression mechanism and mediators that shape process of suppression. Specifically, information is not available concerning immunomodulatory effects drugs which are involved in restoration. In this study, we investigated Cimetidine modulation patients with injury 20-60%. Two groups were study; one group treated 15 mg/kg per day while other placebo. Peripheral blood mononuclear cell (PBMC) expressing CD3, CD4, CD8, CD19 CD3/HLA-DR was analyzed by flow cytometry. Cell proliferation assay using H3 thymidine performed PBMC samples. The showed a significant suppression rate post-burn (p = 0.001). We observed reduction lymphocyte count 0.001) frequency CD3 0.007) CD4 T cells patients. Also, CD 19+ HLA DR+ increased compare normal donors injury. Treatment CD8+ patient's peripheral blood. restored treatment 0.02). Our data indicates may beneficial mediated immunity
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