IL-27: A Key Player in Immune Regulation

摘要: Interleukin-27 plays an important role in the regulation of immune response. IL-27 signaling mediated by its heterodimeric IL-27Rα/gp130 receptor activates multiple cascades, including STAT1 and STAT3, Akt/mTOR, ERK, p38 MAPK pathways. Up- downregulation both subunits cross talk between cell populations regulate magnitude signal transduction. Transduction stimulatory is also limited through a reciprocal feedback loop involving SOCS3. Initial studies focused on proinflammatory activities IL-27. induces expression T-bet hence promotes Th1 differentiation augments CD8+ T cell- NK cell-mediated cytotoxicity. Simultaneously, limits inflammation ability to negatively GATA-3 ROR-γt, key transcription factors Th2 Th17 cells, respectively. In contrast, Tr1 positively stimulated upregulation c-Maf Ahr further contributing limitation inflammation. Here, we have discussed downstream from main molecular targets subsets Th1, Th2, Th17, Treg, Tr1, Tfh population as well B DCs, macrophages.