Renal dysfunction after orthotopic liver transplantation.

摘要: Background. Identification of risk factors acute renal failure (ARF) after orthotopic liver transplantation (OLT) may avoid the development and attenuate impact on patient outcome. Therefore, incidence ARF OLT at Siriraj Hospital were analyzed. Methods. The study was retrospectively analyzed from patients between January 2002 December 2009. defined as an increased in serum creatinine level more than 1.5 times within first week postoperation compared with preoperative level. Results. A total 81 transplant mean age 52.45 years (range, 22 to 71) there 25 women (30.86%) 56 men (69.14%). Indications for end-stage cirrhosis (n ¼ 43, 53.09%), hepatocellular carcinoma 36, 44.44%), fulminant hepatic 2, 2.47%). Fifty-eight (71.60%) developed ARF, perioperative mortality these 18.97%. univariate analysis identified presence coagulopathy, prolonged intraoperative hypotension, blood loss, postoperative hypotension ARF. By multivariate analysis, 30 minutes independent During periods, group required components transfusion, longer intensive care unit stay, higher in-hospital mortality. Seven (12.07%) replacement therapy. Four (9.52%) chronic failure, one them long-term hemodialysis. Conclusions. a common complication OLT, which caused morbidity Although some dialysis, most recovered normal function. Prolonged OLT.