Polymeric microneedles for transdermal protein delivery.
作者： Yanqi Ye , Jicheng Yu , Di Wen , Anna R. Kahkoska , Zhen Gu
DOI: 10.1016/J.ADDR.2018.01.015
关键词:
摘要: The intrinsic properties of therapeutic proteins generally present a major impediment for transdermal delivery, including their relatively large molecule size and susceptibility to degradation. One solution is utilize microneedles (MNs), which are capable painlessly traversing the stratum corneum directly translocating protein drugs into systematic circulation. MNs can be designed incorporate appropriate structural materials as well therapeutics or formulations with tailored physicochemical properties. This platform technique has been applied deliver both locally systemically in applications ranging from vaccination diabetes cancer therapy. review surveys current design use polymeric delivery. clinical potential future translation also discussed.
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