p19ras Represses proliferation of non-small cell lung cancer possibly through interaction with Neuron-Specific Enolase (NSE)
作者： Sang-Min Jang , Jung-Woong Kim , Chul-Hong Kim , Daehwan Kim , Sangmyung Rhee
DOI: 10.1016/J.CANLET.2009.08.005
关键词:
摘要: p19(ras) is an alternative splicing product of the proto-oncogene c-H-ras pre-mRNA. In this study, we identified a novel p19(ras)-binding protein, Neuron-Specific Enolase (NSE), using yeast two-hybrid method. NSE one enolase families that convert 2-phospho-d-glycerate (PGA) to phosphoenolpyruvate (PEP) in glycolysis pathway. both endogenous and over-expressed systems, confirmed interactions between via co-immunoprecipitation assay. We also interaction region p19(ras), which required for binding with NSE. When full-length C-terminal are bound NSE, it inhibits enzymatic activity Furthermore, interacted alpha (Enoalpha) repressed its vitro. lung cancer cell proliferation mostly increased by H1299 cells. Taken together, these results suggest regulator suppress through
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