Endothelium-mediated regulation of coronary tone
作者： E. Bassenge
DOI: 10.1007/978-3-642-72461-9_8
关键词:
摘要: To what extent endothelial autacoids like endothelium-derived relaxant factor/nitric oxide (EDRF/NO), in addition to neural-humoral factors, are involved the regulation of myocardial perfusion, is presently not known. Therefore, we investigated conscious, chronically instrumented dogs effect stereospecific inhibitors (NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine (L-NNA), NG-monomethylester-L-arginine (L-NAME)) nitric oxide-synthesis and -release on epicardial coronary tone (and diameter) perfusion. A hydraulic cuff was used, produce reactive hyperemia keep perfusion constant over short periods. 40 mg/kg L-NNA i. v. caused a long-lasting increase mean arterial blood pressure from 94±8 129±11 mmHg simultaneous decrease diameter by 2.8±0.3%. Heart rate dropped 87 58 min−1, but double product heart only 8±2% (p = 0.05). The maximal conductance during peak (after 20 s ischemia) indicating complete dilation diminished 48% after L-NNA.
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sci-hub.st 参考文章(35)
A. B. Fisher, A. Chander, J. Reicherter, Uptake and degradation of natural surfactant by isolated rat granular pneumocytes. American Journal of Physiology-cell Physiology. ,vol. 253, ,(1987) , 10.1152/AJPCELL.1987.253.6.C792
Ferid Murad, Modulation of the Guanylate Cyclase -cGMP System by Vasodilators and the Role of Free Radicals as Second Messengers Springer, Boston, MA. pp. 157- 164 ,(1989) , 10.1007/978-1-4684-8532-5_15
T B McCall, N K Boughton-Smith, R M J Palmer, B J R Whittle, S Moncada, Synthesis of nitric oxide from l-arginine by neutrophils. Release and interaction with superoxide anion Biochemical Journal. ,vol. 261, pp. 293- 296 ,(1989) , 10.1042/BJ2610293
John D. Catravas, Una S. Ryan, Transduction Mechanisms, C. Norman Gillis, Vascular Endothelium Receptors and Transduction Mechanisms Plenum Press : Published in cooperation with NATO Scientific Affairs Division. ,(1989)
Salvador Moncada, Richard M.J. Palmer, E.Annie Higgs, Biosynthesis of nitric oxide from l-arginine: A pathway for the regulation of cell function and communication Biochemical Pharmacology. ,vol. 38, pp. 1709- 1715 ,(1989) , 10.1016/0006-2952(89)90403-6
H. Bult, G. E. Boeckxstaens, P. A. Pelckmans, F. H. Jordaens, Y. M. Van Maercke, A. G. Herman, Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature. ,vol. 345, pp. 346- 347 ,(1990) , 10.1038/345346A0
L J Ignarro, Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circulation Research. ,vol. 65, pp. 1- 21 ,(1989) , 10.1161/01.RES.65.1.1
Joji Ando, Teruhiko Komatsuda, Akira Kamiya, Cytoplasmic calcium response to fluid shear stress in cultured vascular endothelial cells. In Vitro Cellular & Developmental Biology – Plant. ,vol. 24, pp. 871- 877 ,(1988) , 10.1007/BF02623896
R. Busse, A. Lackhoff, E. Bassenge, Endothelium-derived relaxant factor inhibits platelet activation. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 336, pp. 566- 571 ,(1987) , 10.1007/BF00169315
Ulrich Nellessen, Tommy C. Lee, Tim A. Fischell, Robert Ginsburg, Tohru Masuyama, Edwin L. Alderman, John S. Schroeder, Effects of acetylcholine on epicardial coronary arteries after cardiac transplantation without angiographic evidence of fixed graft narrowing The American Journal of Cardiology. ,vol. 62, pp. 1093- 1097 ,(1988) , 10.1016/0002-9149(88)90555-3