Synthesis, characterization and in vitro evaluation of a series of novel polyrotaxane-based delivery system for artesunate.
作者： Xiao-Shun Gong , Rui-Jian Jiang , Xia-Li Liao , Hu-Die Xie , Xue Ma
DOI: 10.1016/J.CARRES.2015.04.021
关键词:
摘要: A series of novel artesunate-polyrotaxanes (ATS-PRs) with folic acid capped, in which artesunate (ATS) was covalently bound to a cyclodextrin (CD) the polyrotaxane (PR), were synthesized and characterized by NMR, XRD, TG DSC. The cytotoxicities ATS-PRs on human colon cancer cell lines HT-29, SW480, HTC116 DLD-1 showed that their antitumor activities better than dihydroartemisinin (DHA). These may provide useful approach development highly effective drug candidate for chemotherapy cancer.
sci-hub.se 参考文章(22)
Rong-rong He, Huai-jun Zhou, Progress in research on the anti-tumor effect of artesunate Chinese Journal of Integrative Medicine. ,vol. 14, pp. 312- 316 ,(2008) , 10.1007/S11655-008-0312-0
C Riganti, S Doublier, D Viarisio, E Miraglia, G Pescarmona, D Ghigo, A Bosia, Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression. British Journal of Pharmacology. ,vol. 156, pp. 1054- 1066 ,(2009) , 10.1111/J.1476-5381.2009.00117.X
Thomas Efferth, Marco Giaisi, Annette Merling, Peter H. Krammer, Min Li-Weber, Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells PLoS ONE. ,vol. 2, pp. e693- ,(2007) , 10.1371/JOURNAL.PONE.0000693
Lin-Na Li, Hua-Dong Zhang, Shou-Jun Yuan, Zeng-Yue Tian, Lin Wang, Zhi-Xian Sun, Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/β-catenin pathway International Journal of Cancer. ,vol. 121, pp. 1360- 1365 ,(2007) , 10.1002/IJC.22804
Akira Harada, Jun Li, Mikiharu Kamachi, Yasuyuki Kitagawa, Yukiteru Katsube, STRUCTURES OF POLYROTAXANE MODELS Carbohydrate Research. ,vol. 305, pp. 127- 129 ,(1997) , 10.1016/S0008-6215(97)00276-0
A.V. Kabanov, H.E. Gendelman, Nanomedicine in the diagnosis and therapy of neurodegenerative disorders. Progress in Polymer Science. ,vol. 32, pp. 1054- 1082 ,(2007) , 10.1016/J.PROGPOLYMSCI.2007.05.014
Rui-Jian Jiang, Bo Yang, Zhen-Kun Liu, Yu-Lin Zhao, Xia-Li Liao, Jian Yang, Chuan-Zhu Gao, Fen Wang, Bin Han, A novel polyrotaxane-based delivery system for scutellarin: preparation, characterization, and in vitro evaluation. Carbohydrate Research. ,vol. 380, pp. 149- 155 ,(2013) , 10.1016/J.CARRES.2013.07.009
Thorbjørn Terndrup Nielsen, Véronique Wintgens, Catherine Amiel, Reinhard Wimmer, Kim Lambertsen Larsen, Facile Synthesis of β-Cyclodextrin-Dextran Polymers by “Click” Chemistry Biomacromolecules. ,vol. 11, pp. 1710- 1715 ,(2010) , 10.1021/BM9013233
Pakatip Ruenraroengsak, Janice M. Cook, Alexander T. Florence, Nanosystem drug targeting: Facing up to complex realities Journal of Controlled Release. ,vol. 141, pp. 265- 276 ,(2010) , 10.1016/J.JCONREL.2009.10.032
Tomasz Girek, Cyclodextrin-based polyrotaxanes Journal of Inclusion Phenomena and Macrocyclic Chemistry. ,vol. 76, pp. 237- 252 ,(2013) , 10.1007/S10847-012-0253-2